Lee County Tax Collector (Vehicle Registration & Title) 201 Jefferson St.Tupelo Mississippi 38804 MS USA 201 Jefferson St.Directions (662) 841-9034 Monday 08:00 am - 05:00 pm Tuesday 08:00 am - 05:00 pm Wednesday 08:00 am - 05:00 pm Thursday 08:00 am - 05:00 pm Friday 08:00 am - 05:00 pm Saturday Closed Sunday Closed