Issaquena County tax Collector (Vehicle Registration & Title) 129 Court St.Mayersville Mississippi 39113 MS USA 129 Court St.Directions (662) 873-4665 Monday 08:00 am - 05:00 pm Tuesday 08:00 am - 05:00 pm Wednesday 08:00 am - 05:00 pm Thursday 08:00 am - 05:00 pm Friday 08:00 am - 05:00 pm Saturday Closed Sunday Closed