Driver License & Vehicle Registration Office 324 S. Main St.De Soto Missouri 63020 MO USA 324 S. Main St.Directions (636) 586-9228 Monday 08:30 am - 05:00 pm Tuesday 08:30 am - 05:00 pm Wednesday 08:30 am - 05:00 pm Thursday 08:30 am - 05:00 pm Friday 08:30 am - 05:00 pm Saturday Closed Sunday Closed